Apoquel (oclacitinib chewable tablet) Chewable for Dogs, 5.4mg, 60 tablets

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$170.43 Autoship Price
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About This Item

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Apoquel is an oral chewable tablet that works differently than other skin allergy medications for dogs. It goes straight to the source to help relieve itch and inflammation at its core addressing the underlying cause of irritation and soothing allergic reactions. Apoquel Chewable provides rapid relief from allergic dermatitis and was demonstrated to control allergic pruritus within 24 hrs. Apoquel is ideal for both short or long-term treatment and can help to offer relief without many of the side effects associated with other medications.IMPORTANT SAFETY INFORMATION: Do not use APOQUEL CHEWABLE in dogs less than 12 months of age or those with serious infections. APOQUEL CHEWABLE may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. Consider the risks and benefits of treatment in dogs with a history of recurrence of these conditions. New neoplastic conditions (benign and malignant) were observed in clinical studies and post-approval. APOQUEL CHEWABLE has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporines. Do not use in breeding, pregnant, or lactating dogs. Most common side effects are vomiting and diarrhea. APOQUEL CHEWABLE has been used safely with many common medications including parasiticides, antibiotics and vaccines. See full prescribing information below.

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Ingredients

Instructions

FAQ

Learn More About Apoquel From Our Team of Experts

The Welcome Taste of Fast-Acting  Allergic Itch Relief

The first and only chewable treatment for the control of allergic itch in dogs. Apoquel Chewable is a tasty pork liver-flavored chewable. A recent study showed that Apoquel Chewable was accepted by over 90% of dogs. [1]

Apoquel Stops Allergic Itch Right at the Source

If your dog is scratching, licking or chewing like crazy, you want to provide relief that starts acting quickly. Apoquel Chewable effectively controls allergic itch within 24 hours [2].

Approved for Short-Term and Long-Term Use

Apoquel Chewable can be used for long-term maintenance or short-term therapy [3,4].
9 millimeter equals 3.6 milligrams, 10 millimeter equals 5.4 milligrams, and 15 millimeter equals 16 milligrams

Struggling with Giving Pills?

A survey showed 70% of pet parents preferred a chewable tablet* and 65% of pet parents struggle with conventional tablet-based therapies [5]. With a treat-like formulation, Apoquel Chewable may simplify dosing and help eliminate the stress from giving pills. Talk to your vet to see if Apoquel Chewable could be right for your dog. It's easy to give and comes in 3 strengths to suit your dog’s body weight.

*Responses based on owner review of Apoquel Tablet and Apoquel Chewable product profiles in a survey

About Apoquel

Apoquel is a revolutionary oral medication for dogs with allergic itch. It works differently than other medications by going right to the source to stop the underlying cause of itch in dogs with skin allergies [6]. Apoquel is offered as either a tablet or chewable formulation with a veterinarian's prescription. Talk to your vet about what's best for your dog.

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Important Safety Information

See full Prescribing Information. Do not use Apoquel Chewable in dogs less than 12 months of age or those with serious infections. Apoquel Chewable may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. Consider the risks and benefits of treatment in dogs with a history of recurrence of these conditions.  New neoplastic conditions (benign and malignant) were observed in clinical studies and post-approval.  Apoquel Chewable has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporines. Do not use in breeding, pregnant, or lactating dogs. Most common side effects are vomiting and diarrhea. Apoquel Chewable has been used safely with many common medications including parasiticides, antibiotics and vaccines.

INDICATIONS: Control of pruritus (itching) associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age.

References:

[1] Visser M, Walsh K, King V, Sture G, Caneva L. Acceptance of oclacitinib maleate (Apoquel) chewable tablets in client-owned dogs with allergic and atopic dermatitis. BMC veterinary research. 2022;18(1):103. doi:10.1186/s12917-022-03210-x 

[2] Data on file: Study Report A161C-US-21-C02, Zoetis Inc., 2022.

[3] Cosgrove SB, Wren JA, Cleaver DM, et al. Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis. Vet Dermatol. 2013;24(5):479- e114. doi: 10.1111/vde.12047.

[4] Cosgrove SB, Cleaver DM, King VL, et al. Long-term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy and quality of life. Vet Dermatol. 2015;26(3):171-179, e35. doi: 10.1111/vde.12194.

[5] Data on file, ZMR: Adelphi/PROVE: Pet Owner Preferences Chewable Vs. Conventional Canine Pruritus, Zoetis Services LLC, March 2023. N= 262 pet owners.

[6] Gonzales AJ, Bowman JW, Fici GJ, et al. Oclacitinib (APOQUEL(®) is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. Journal of Veterinary Pharmacology and Therapeutics. 2014;37(4):317-324. doi:10.1111/vp.12101. 

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4.7
Rated 4.7 out of 5 stars
7889 Ratings
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Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

84% Positive

Effectiveness

82% Positive

Ingredients

83% Positive

Long-Term Benefits

82% Positive

2851 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 4 out of 5 stars
By Megan on Oct 18, 2025

Magic

So my dog has had terrible allergies since he was a puppy. I take him to the vet constantly. This round; however, I got a coupon from Chewy in the mail for the chewable

So my dog has had terrible allergies since he was a puppy. I take him to the vet constantly. This round; however, I got a coupon from Chewy in the mail for the chewable version of apoquel. I decided to just try it but normally I have to take him in to get a steroid before taking the apoquel because his allergies are too far gone. THIS TYPE though I did not and it’s only been a week of him taking it. He looks so much better!!!

Rated 2 out of 5 stars
By Tammy on Oct 10, 2025

Shipped wrong dosage and hasn’t sent a return label yet over a month!

I ordered 16mg apoquel and then the next shipment came was 5.4 to be split in half. I am not paying almost $200. for the wrong dosage a third of the correct dose

I ordered 16mg apoquel and then the next shipment came was 5.4 to be split in half. I am not paying almost $200. for the wrong dosage a third of the correct dose. She said she would send me a return label reluctantly and I didn’t receive it yet for a month! I’m done with this company because of the disappointing customer service I have been through. I’m a senior citizen on a fixed income and this has put a hardship on me. I’m going to cancel my subscription with chewy today. I have not used the lower dose because I was told it had to be sent back! I don’t think it’s safe to send medication to anyone else because you don’t know what it has been done to. But I don’t want to pay almost 200.00 for the wrong medication!

Rated 4 out of 5 stars
By Marcia on Sep 27, 2025

WORKING WITH CHEWY

We got off to a rocky start when I first tried to setup auto ship. I received different stories from both the Vet and Chewy. Both told me they didn't work with each

We got off to a rocky start when I first tried to setup auto ship. I received different stories from both the Vet and Chewy. Both told me they didn't work with each other. I find the communication was too convoluted to even try to explain... but, let me just say, my blood pressure was so high that I ended up being way too upset with my vet. I ended up having to apologize, in person, to my vet. Once auto ship is set up with Chewy, everything is working fine. The only issue I had today when changing auto ship was to alert the pharmacy tech that I wish the indication to change the date of auto ship was much more evident than it is because I definitely looked and ended up having to use CHAT. The pharmacy tech conversation was perfect with Brook. The price break is worth it in the end.

Rated 4 out of 5 stars
By Darlene on Sep 23, 2025

Has worked with dosage adjustments

Easy to use chewable tablet my dog takes just like any other treat. I follow with a few pieces of kibble to make sure. It seems to wear off at about hour 20 of the

Easy to use chewable tablet my dog takes just like any other treat. I follow with a few pieces of kibble to make sure. It seems to wear off at about hour 20 of the 24hrs (daily) so I give in am and those 4 hours are at nighttime - so far working. Had to go twice daily at one point but for fall seasonal ragweed allergies it seems to be effective treatment. Gotta get to frost and we will be all set! Likely 2 weeks or a month to go! I like that If I see any side effects I could stop it over giving a Cytopoint shot which gave him 3 weeks of diarrhea last year & is in his system a while. A bit expensive but will take it over vet bills to treat hotspots/chew wounds etc. Plus I have a young dog so not likely he’s got any existing medical issues yet to be affected by this. This is also easier if you need to have someone care for your dog at any point. Easy instructions. FYI I’m also giving Nusentia probiotic, salmon oil in his salmon Canidae dry food. Plus a multivitamin chew. Wiping down thoroughly after coming in from potty walk too. And vacuuming with good hepa filter daily.

Rated 5 out of 5 stars
By Albert on Sep 24, 2025

EFFICACY OF APOQUEL FOR TREATMENT OF DOG ALLERGIES AND ITCHING

My pug has been taking Apoquel for treatment of her allergies. My impression of the medication is that it is reasonably effective for those purposes. My partner's

My pug has been taking Apoquel for treatment of her allergies. My impression of the medication is that it is reasonably effective for those purposes. My partner's experience from using Apoquel for those same purposes, in connection with her pug has led her to the same conclusion that i've reached. With both our pugs, it has been necessary to administer Benadryl in combination with the Apoquel. My partner's pug also gets an injection of another prescription medication every other month in order for her pug to achieve satisfactory relief. Both are veterinarians have informed us that resistance to the effect of Apoquel occurs after prolonged use and that over time temporary cessations of Apoquel's use is advisable reduce the likelihood of such resistance becoming permanent.

Rated 5 out of 5 stars
By Karen on Oct 9, 2025

No more itching!

Poor Ivy has late summer skin allergies that cause severe itching. She would bite and chew her feet and scratch her neck until she was raw. Her vet prescribed Apoquel

Poor Ivy has late summer skin allergies that cause severe itching. She would bite and chew her feet and scratch her neck until she was raw. Her vet prescribed Apoquel and the scratching stopped in just hours. Now I start giving her the tablets as soon as I notice her starting to itch in late July and continue daily until late October when we get frosty temps. No more scratching and biting and hair loss! Ivy is comfortable and gets to enjoy her walks in late summer again.

Rated 5 out of 5 stars
By Pamela on Oct 2, 2025

Apoquel is a life saver for rescue Pittie!

Our boy has terrible allergy issues. He bites, licks and scratches himself constantly without Apoquel. This product has been a life saver for our 95lb rescue Pittie

Our boy has terrible allergy issues. He bites, licks and scratches himself constantly without Apoquel. This product has been a life saver for our 95lb rescue Pittie. Apoquel did not work instantly, but in about 2 weeks of two 16mg tabs per day, he is much more comfortable, and doesn’t have any itchy issues. We have limited his treats, and also changed him to a limited ingredient diet. He is now 10 years old and doing great with Apoquel.

Rated 4 out of 5 stars
By Vicki on Oct 16, 2025

Works great, BUT

This stuff works really good for my heeler. Her allergies are itchy skin. The only reason I have 4 stars is due to the price. No way should dog’s pills for allergies

This stuff works really good for my heeler. Her allergies are itchy skin. The only reason I have 4 stars is due to the price. No way should dog’s pills for allergies be $3.07 per pill!!! It is absolute robbery. I recently for an alternate brand that is just as good. It is only $2.00 a pill which is still too high, but saves you money.

Rated 3 out of 5 stars
By Josh on Oct 16, 2025

Great price-bad shipping

For the price, it is unbeatable. The ease it was to order, contacting the vet, and notifications was all superb. The ONLY bad thing was the week long delay with

For the price, it is unbeatable. The ease it was to order, contacting the vet, and notifications was all superb. The ONLY bad thing was the week long delay with the shipping platform, Fed-Ex. It went feom Kentucky to Oregon, to Montana and then to me. It was a week late. Hopefully it will be better in the future.

Rated 5 out of 5 stars
By Albert on Sep 25, 2025

This has worked wonders for both of our German Shepherds!!!

Both of our dogs deal with real bad skin itching. Loki's was so bad he would rub his paws raw. Atlas was not as bad, but constantly itched through out the year

Both of our dogs deal with real bad skin itching. Loki's was so bad he would rub his paws raw. Atlas was not as bad, but constantly itched through out the year. We tried multiple different things such as different food, fish oils, dog is human, and others. This medication started working immediately on both dogs. Now after a week Loki's paws are healing up and Atlas does not constantly itch.