10 Best Dog Calming Care & Anxiety Supplements 2025: According to Reviews | Chewy

The 10 Best Dog Calming Care & Anxiety Supplements

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How we created this dog calming care & anxiety supplement list

We leveraged input from our veterinarians and artificial intelligence to identify key considerations to help you find the best dog calming care & anxiety supplement.
We scanned thousands of customer reviews and ratings and scored each product based on its performance against each of the key considerations. We then considered how popular a product is with Chewy customers and combined that with its key consideration scores to create the list of the best dog calming care & anxiety supplements.

Key dog calming care & anxiety supplement considerations

Dosage

Effectiveness

Ingredients

Safety

1
Pupford Beef Tendon Dog Chews, 10 count
Pupford Beef Tendon Dog Chews, 10 count
Pupford Beef Tendon Dog Chews, 10 count
Pupford Beef Tendon Dog Chews, 10 count
Pupford Beef Tendon Dog Chews, 10 count
Pupford Beef Tendon Dog Chews, 10 count
Pupford Beef Tendon Dog Chews, 10 count
Pupford Beef Tendon Dog Chews, 10 count

Pupford Beef Tendon Dog Chews, 10 count

Rated 4.5 out of 5 stars
115
$26.99Chewy Price
($2.70/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Is this dog calming care & anxiety supplement right for my pet?

All Breed Sizes  •  All Lifestages

Our ratings

Dosage

4.5/5
Great

Effectiveness

4.5/5
Great

Ingredients

4.6/5
Excellent

Safety

4.6/5
Excellent

Pros

  • Affordable: Many pet parents appreciate the affordable price point of these chews, making them a worthwhile investment for any dog owner.
  • Long-lasting: Several pet parents noted that the chews last longer than expected, providing a satisfying chew for dogs and helping to keep them engaged.
  • Easy to Digest: The chews are made with 100% pure beef and are easy to digest, making them gentle on teeth and reducing the risk of choking.

Cons

  • Not Appealing to All Dogs: While many dogs love the chews, some may not find them appealing, leading to waste or frustration.
  • May Not Last as Long as Advertised: Although several pet parents noted that the chews last longer than expected, others mentioned that they did not last as long as advertised.
2
Purina Pro Plan Veterinary Diets Calming Care Liver Flavored Powder Calming Supplement for Dogs, 30 count
Purina Pro Plan Veterinary Diets Calming Care Liver Flavored Powder Calming Supplement for Dogs, 30 count
Purina Pro Plan Veterinary Diets Calming Care Liver Flavored Powder Calming Supplement for Dogs, 30 count
Purina Pro Plan Veterinary Diets Calming Care Liver Flavored Powder Calming Supplement for Dogs, 30 count
Purina Pro Plan Veterinary Diets Calming Care Liver Flavored Powder Calming Supplement for Dogs, 30 count
Purina Pro Plan Veterinary Diets Calming Care Liver Flavored Powder Calming Supplement for Dogs, 30 count
Purina Pro Plan Veterinary Diets Calming Care Liver Flavored Powder Calming Supplement for Dogs, 30 count
Purina Pro Plan Veterinary Diets Calming Care Liver Flavored Powder Calming Supplement for Dogs, 30 count

Purina Pro Plan Veterinary Diets Calming Care Liver Flavored Powder Calming Supplement for Dogs, 30 count

Rated 4.2 out of 5 stars
1,210
$33.99Chewy Price
Promo, Save 50% on your first Autoship

Is this dog calming care & anxiety supplement right for my pet?

All Breed Sizes  •  All Lifestages

Our ratings

Dosage

4.4/5
Great

Effectiveness

4.4/5
Great

Ingredients

4.3/5
Great

Safety

4.2/5
Great

Pros

  • Easy to Administer: Many pet parents found it easy to give to their dogs, with some even enjoying the taste.
  • Calming Effect: The product has a noticeable calming effect on dogs, reducing anxiety and stress.
  • (Removed - duplicate point)

Con

  • Time to See Results: It may take several weeks to see the full effects of the product, which can be frustrating for pet parents seeking a quick solution.
3
Vibeful Calming Melatonin Peanut Butter Flavored Soft Chews Calming Supplement for Dogs, 90-Count
Vibeful Calming Melatonin Peanut Butter Flavored Soft Chews Calming Supplement for Dogs, 90-Count
Vibeful Calming Melatonin Peanut Butter Flavored Soft Chews Calming Supplement for Dogs, 90-Count
Vibeful Calming Melatonin Peanut Butter Flavored Soft Chews Calming Supplement for Dogs, 90-Count
Vibeful Calming Melatonin Peanut Butter Flavored Soft Chews Calming Supplement for Dogs, 90-Count
Vibeful Calming Melatonin Peanut Butter Flavored Soft Chews Calming Supplement for Dogs, 90-Count
Vibeful Calming Melatonin Peanut Butter Flavored Soft Chews Calming Supplement for Dogs, 90-Count
Vibeful Calming Melatonin Peanut Butter Flavored Soft Chews Calming Supplement for Dogs, 90-Count

Vibeful Calming Melatonin Peanut Butter Flavored Soft Chews Calming Supplement for Dogs, 90-Count

Rated 4.1 out of 5 stars
401
$19.99Chewy Price
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Is this dog calming care & anxiety supplement right for my pet?

All Breed Sizes  •  All Lifestages

Our ratings

Dosage

4.3/5
Great

Effectiveness

4.3/5
Great

Ingredients

4.3/5
Great

Safety

4.3/5
Great

Pros

  • Effective Calming: Reduces anxiety and stress in many dogs, helping them relax and sleep better.
  • Delicious Flavor: Most dogs love the taste, making it easy to administer.
  • Easy to Administer: Soft chews are comfortable for dogs to consume.
  • Natural Formula: Pet-safe ingredients provide a non-pharmaceutical alternative for anxious dogs.
  • Versatile Use: Effective in calming dogs during thunderstorms, fireworks, car rides, and more.

Cons

  • Dosage Limitations: Recommended dosage may not be effective for larger dogs, according to some pet parents.
  • Adverse Reactions: Some pet parents reported that their dogs may experience gastrointestinal issues or lethargy after using the product.
4
VetIQ Calming Soft Chew Calming Supplement for Dogs, 60 count
VetIQ Calming Soft Chew Calming Supplement for Dogs, 60 count
VetIQ Calming Soft Chew Calming Supplement for Dogs, 60 count
VetIQ Calming Soft Chew Calming Supplement for Dogs, 60 count
VetIQ Calming Soft Chew Calming Supplement for Dogs, 60 count
VetIQ Calming Soft Chew Calming Supplement for Dogs, 60 count
VetIQ Calming Soft Chew Calming Supplement for Dogs, 60 count
VetIQ Calming Soft Chew Calming Supplement for Dogs, 60 count

VetIQ Calming Soft Chew Calming Supplement for Dogs, 60 count

Rated 4.3 out of 5 stars
738
$11.98Chewy Price
Promo, Save 50% on your first Autoship

Is this dog calming care & anxiety supplement right for my pet?

All Breed Sizes  •  All Lifestages

Our ratings

Dosage

4.2/5
Great

Effectiveness

4.3/5
Great

Ingredients

4.3/5
Great

Safety

4.3/5
Great

Pros

  • Effective Calming: Quickly calms dogs in stressful situations, reducing anxiety and stress.
  • Easy to Administer: Soft and tasty chews make it easy to give to dogs.
  • Natural Ingredients: Made with natural ingredients, suitable for all breeds and sizes.
  • Quick Results: Many pet parents notice a difference within 15-40 minutes.
  • Affordable: Priced reasonably, making it a great value for pet parents.

Cons

  • Strong Smell: Some pet parents report a strong, unpleasant odor from the chews.
  • Individual Results Vary: Effectiveness can vary depending on the individual dog and its specific needs
5
ThunderShirt Classic Anxiety & Calming Vest for Dogs, Heather Grey, Large
ThunderShirt Classic Anxiety & Calming Vest for Dogs, Heather Grey, Large
ThunderShirt Classic Anxiety & Calming Vest for Dogs, Heather Grey, Large
ThunderShirt Classic Anxiety & Calming Vest for Dogs, Heather Grey, Large
ThunderShirt Classic Anxiety & Calming Vest for Dogs, Heather Grey, Large
ThunderShirt Classic Anxiety & Calming Vest for Dogs, Heather Grey, Large
ThunderShirt Classic Anxiety & Calming Vest for Dogs, Heather Grey, Large
ThunderShirt Classic Anxiety & Calming Vest for Dogs, Heather Grey, Large

ThunderShirt Classic Anxiety & Calming Vest for Dogs, Heather Grey, Large

Rated 4.1 out of 5 stars
2,054
$46.99Chewy Price
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Is this dog calming care & anxiety supplement right for my pet?

All Breed Sizes  •  All Lifestages

Our ratings

Dosage

3.9/5
Good

Effectiveness

4.2/5
Great

Ingredients

4.2/5
Great

Safety

4.3/5
Great

Pros

  • Calms Anxiety: Reduces anxiety and stress in dogs during thunderstorms, fireworks, and other loud noises.
  • Comfortable Fit: Easy to put on and take off, with a comfortable and snug fit for dogs.
  • Effective Solution: Helps with separation anxiety, car rides, and other behavioral issues.
  • Well-Made Product: Made of high-quality, durable materials that provide a gentle, constant pressure.
  • Easy to Use: Simple to put on and adjust, making it a convenient solution for pet parents.

Cons

  • Sizing Issues: Some pet parents experienced difficulties with sizing, finding the product too big or too small for their dogs.
  • Velcro Concerns: A few reviewers reported that the velcro was loud or uncomfortable for their dogs.
6
Pawstruck Dental Chew Brush Small Dogs Treats, 15 count
Pawstruck Dental Chew Brush Small Dogs Treats, 15 count
Pawstruck Dental Chew Brush Small Dogs Treats, 15 count
Pawstruck Dental Chew Brush Small Dogs Treats, 15 count

Pawstruck Dental Chew Brush Small Dogs Treats, 15 count

Rated 4.4 out of 5 stars
38
$15.99Chewy Price
($1.07/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Is this dog calming care & anxiety supplement right for my pet?

Small Breed Sizes, Medium Breed Sizes  •  All Lifestages

Our ratings

Dosage

4.2/5
Great

Effectiveness

4.5/5
Great

Ingredients

4.7/5
Excellent

Safety

4.2/5
Great
7
Finn Calming Aid Soft Chew Dog Supplement, 90 count
Finn Calming Aid Soft Chew Dog Supplement, 90 count
Finn Calming Aid Soft Chew Dog Supplement, 90 count
Finn Calming Aid Soft Chew Dog Supplement, 90 count
Finn Calming Aid Soft Chew Dog Supplement, 90 count
Finn Calming Aid Soft Chew Dog Supplement, 90 count
Finn Calming Aid Soft Chew Dog Supplement, 90 count
Finn Calming Aid Soft Chew Dog Supplement, 90 count
Finn Calming Aid Soft Chew Dog Supplement, 90 count

Finn Calming Aid Soft Chew Dog Supplement, 90 count

Rated 4.3 out of 5 stars
540
$34.00Chewy Price
Promo, Save 50% on your first Autoship

Is this dog calming care & anxiety supplement right for my pet?

All Breed Sizes  •  All Lifestages

Our ratings

Dosage

4.6/5
Excellent

Effectiveness

4.6/5
Excellent

Ingredients

4.6/5
Excellent

Safety

4.6/5
Excellent

Pros

  • Effective in reducing anxiety: Many pet parents reported that the product effectively reduced their dog's anxiety levels and promoted relaxation.
  • Natural ingredients: The product contains only natural ingredients, making it safe for dogs and appealing to pet parents who prefer natural remedies.
  • High quality: Pet parents appreciate the high quality of the product and its durability.

Con

  • Side effects: Some pet parents reported minor side effects such as digestive issues, while others noted no adverse reactions.
8
Zesty Paws Hemp Elements Calming Hemp OraStix Peppermint Flavored Dental Chews Melatonin Supplement for Dogs, 25-oz bag
Zesty Paws Hemp Elements Calming Hemp OraStix Peppermint Flavored Dental Chews Melatonin Supplement for Dogs, 25-oz bag
Zesty Paws Hemp Elements Calming Hemp OraStix Peppermint Flavored Dental Chews Melatonin Supplement for Dogs, 25-oz bag
Zesty Paws Hemp Elements Calming Hemp OraStix Peppermint Flavored Dental Chews Melatonin Supplement for Dogs, 25-oz bag
Zesty Paws Hemp Elements Calming Hemp OraStix Peppermint Flavored Dental Chews Melatonin Supplement for Dogs, 25-oz bag
Zesty Paws Hemp Elements Calming Hemp OraStix Peppermint Flavored Dental Chews Melatonin Supplement for Dogs, 25-oz bag
Zesty Paws Hemp Elements Calming Hemp OraStix Peppermint Flavored Dental Chews Melatonin Supplement for Dogs, 25-oz bag
Zesty Paws Hemp Elements Calming Hemp OraStix Peppermint Flavored Dental Chews Melatonin Supplement for Dogs, 25-oz bag

Zesty Paws Hemp Elements Calming Hemp OraStix Peppermint Flavored Dental Chews Melatonin Supplement for Dogs, 25-oz bag

Rated 4.3 out of 5 stars
1,167
$24.97Chewy Price
Promo, Save 50% on your first Autoship

Is this dog calming care & anxiety supplement right for my pet?

All Breed Sizes  •  All Lifestages

Our ratings

Dosage

4.2/5
Great

Effectiveness

4.4/5
Great

Ingredients

4.3/5
Great

Safety

4.3/5
Great

Pros

  • Fresh Breath & Oral Health: Many pet parents reported that the treats helped with their dog's oral hygiene and bad breath.
  • Calming Effect: The treats seemed to work well for dogs with mild anxiety, helping to calm them down and reduce stress.
  • Tasty & Loved by Dogs: Many pet parents reported that their dogs loved the taste and flavor of the treats.
  • Natural Ingredients: Many pet parents appreciated that the treats were made with natural ingredients.

Cons

  • Stomach Issues: A few pet parents mentioned that the treats caused stomach issues, such as loose stools or tummy troubles, in their dogs.
  • Small Size: Some pet parents felt that the treats were too small, especially for larger dogs, and that they had to give multiple treats to achieve the desired effect.
9
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle

Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle

Rated 4 out of 5 stars
1,380
$20.99Chewy Price
Promo, Save 50% on your first Autoship

Is this dog calming care & anxiety supplement right for my pet?

All Breed Sizes  •  All Lifestages

Our ratings

Dosage

4.2/5
Great

Effectiveness

4.3/5
Great

Ingredients

4.2/5
Great

Safety

4.3/5
Great

Pros

  • Natural and Safe: Made with natural and holistic ingredients, safe for pets of all ages and sizes.
  • Easy to Administer: Can be easily added to food or water, making it convenient for pet parents.
  • Effective for Anxiety: Many pet parents reported a significant reduction in their pet's anxiety symptoms.
  • Multi-Purpose: Can be used for various anxiety-related issues, including thunderstorms, fireworks, and separation anxiety.
  • Suitable for Multiple Pets: Effective for dogs, cats, horses, and even feral animals.

Con

  • Taste and Smell Issues: Some pets may not like the taste or smell of the product.
10
Pet Releaf Edibites Hip & Joint Releaf Organic Peanut Butter & Banana Flavored Chew CBD Hip & Joint Health Supplement for Medium & Large Dogs, 30 count
Pet Releaf Edibites Hip & Joint Releaf Organic Peanut Butter & Banana Flavored Chew CBD Hip & Joint Health Supplement for Medium & Large Dogs, 30 count
Pet Releaf Edibites Hip & Joint Releaf Organic Peanut Butter & Banana Flavored Chew CBD Hip & Joint Health Supplement for Medium & Large Dogs, 30 count
Pet Releaf Edibites Hip & Joint Releaf Organic Peanut Butter & Banana Flavored Chew CBD Hip & Joint Health Supplement for Medium & Large Dogs, 30 count
Pet Releaf Edibites Hip & Joint Releaf Organic Peanut Butter & Banana Flavored Chew CBD Hip & Joint Health Supplement for Medium & Large Dogs, 30 count

Is this dog calming care & anxiety supplement right for my pet?

Medium Breed Sizes, Large Breed Sizes  •  All Lifestages

Our ratings

Dosage

4.5/5
Great

Effectiveness

4.7/5
Excellent

Ingredients

4.5/5
Great

Safety

4.4/5
Great

Frequently Asked Questions about Dog Calming Care & Anxiety Supplements

How often can I give my dog calming supplements for anxiety?

You can usually give your dog calming supplements for anxiety as often as the package recommends. Different calming supplements have different ingredients and periods of efficacy, so it is important to follow dosage frequency and quantity recommendations. Some calming supplements may be designed to be given daily, while others are made to be given on an as-needed basis. When in doubt, always ask your vet for guidance.

How many calming and anxiety treats can a dog have a day?

A dog can usually have as many calming and anxiety treats a day as the product packaging recommends. Read and follow all supplement directions closely for maximum efficacy and safety. You can also ask your vet for advice on how often to give your dog calming and anxiety treats.