10 Best Dog Calming Care & Anxiety Supplements 2025: According to Reviews | Chewy

The 10 Best Dog Calming Care & Anxiety Supplements

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How we created this dog calming care & anxiety supplement list

We leveraged input from our veterinarians and artificial intelligence to identify key considerations to help you find the best dog calming care & anxiety supplement.
We scanned thousands of customer reviews and ratings and scored each product based on its performance against each of the key considerations. We then considered how popular a product is with Chewy customers and combined that with its key consideration scores to create the list of the best dog calming care & anxiety supplements.

Key dog calming care & anxiety supplement considerations

Dosage

Effectiveness

Ingredients

Safety

1
Pupford Beef Tendon Dog Chews, 10 count
Pupford Beef Tendon Dog Chews, 10 count
Pupford Beef Tendon Dog Chews, 10 count
Pupford Beef Tendon Dog Chews, 10 count
Pupford Beef Tendon Dog Chews, 10 count
Pupford Beef Tendon Dog Chews, 10 count
Pupford Beef Tendon Dog Chews, 10 count
Pupford Beef Tendon Dog Chews, 10 count

Pupford Beef Tendon Dog Chews, 10 count

Rated 4.5 out of 5 stars
124
$26.99Chewy Price
($2.70/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.5/5
Great

Effectiveness

4.5/5
Great

Ingredients

4.6/5
Excellent

Safety

4.6/5
Excellent

Is this dog calming care & anxiety supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredient

Beef Tendon

Special Diet

Natural, High-Protein, Grain-Free, Limited Ingredient Diet
2
Purina Pro Plan Veterinary Diets Calming Care Liver Flavored Powder Calming Supplement for Dogs, 30 count
Purina Pro Plan Veterinary Diets Calming Care Liver Flavored Powder Calming Supplement for Dogs, 30 count
Purina Pro Plan Veterinary Diets Calming Care Liver Flavored Powder Calming Supplement for Dogs, 30 count
Purina Pro Plan Veterinary Diets Calming Care Liver Flavored Powder Calming Supplement for Dogs, 30 count
Purina Pro Plan Veterinary Diets Calming Care Liver Flavored Powder Calming Supplement for Dogs, 30 count
Purina Pro Plan Veterinary Diets Calming Care Liver Flavored Powder Calming Supplement for Dogs, 30 count
Purina Pro Plan Veterinary Diets Calming Care Liver Flavored Powder Calming Supplement for Dogs, 30 count
Purina Pro Plan Veterinary Diets Calming Care Liver Flavored Powder Calming Supplement for Dogs, 30 count

Purina Pro Plan Veterinary Diets Calming Care Liver Flavored Powder Calming Supplement for Dogs, 30 count

Rated 4.3 out of 5 stars
1,339
$33.99Chewy Price
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.4/5
Great

Effectiveness

4.4/5
Great

Ingredients

4.3/5
Great

Safety

4.2/5
Great

Is this dog calming care & anxiety supplement right for my pet?

Breed Size

All Breeds

Lifestage

Adult, All Lifestages

Top Ingredients

Active Ingredients: Bifidobacterium longum BL999 1x109 CFU., Inactive Ingredients: Liver flavor, Maltodextrin. B-2519

Food Flavor

Liver, Meat
3
Zesty Paws Hemp Elements Calming Hemp OraStix Peppermint Flavored Dental Chews Melatonin Supplement for Dogs, 25-oz bag
Zesty Paws Hemp Elements Calming Hemp OraStix Peppermint Flavored Dental Chews Melatonin Supplement for Dogs, 25-oz bag
Zesty Paws Hemp Elements Calming Hemp OraStix Peppermint Flavored Dental Chews Melatonin Supplement for Dogs, 25-oz bag
Zesty Paws Hemp Elements Calming Hemp OraStix Peppermint Flavored Dental Chews Melatonin Supplement for Dogs, 25-oz bag
Zesty Paws Hemp Elements Calming Hemp OraStix Peppermint Flavored Dental Chews Melatonin Supplement for Dogs, 25-oz bag
Zesty Paws Hemp Elements Calming Hemp OraStix Peppermint Flavored Dental Chews Melatonin Supplement for Dogs, 25-oz bag
Zesty Paws Hemp Elements Calming Hemp OraStix Peppermint Flavored Dental Chews Melatonin Supplement for Dogs, 25-oz bag
Zesty Paws Hemp Elements Calming Hemp OraStix Peppermint Flavored Dental Chews Melatonin Supplement for Dogs, 25-oz bag

Zesty Paws Hemp Elements Calming Hemp OraStix Peppermint Flavored Dental Chews Melatonin Supplement for Dogs, 25-oz bag

Rated 4.3 out of 5 stars
1,222
$24.97Chewy Price
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.3/5
Great

Effectiveness

4.4/5
Great

Ingredients

4.4/5
Great

Safety

4.3/5
Great

Is this dog calming care & anxiety supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Hemp Seed Powder, Healthy Teeth & Gum Proprietary Blend (Kelp, Peppermint Oil, Rosemary Extract), Valerian Root

Special Diet

Indoor, No Corn No Wheat No Soy
4
VetIQ Calming Soft Chew Calming Supplement for Dogs, 60 count
VetIQ Calming Soft Chew Calming Supplement for Dogs, 60 count
VetIQ Calming Soft Chew Calming Supplement for Dogs, 60 count
VetIQ Calming Soft Chew Calming Supplement for Dogs, 60 count
VetIQ Calming Soft Chew Calming Supplement for Dogs, 60 count
VetIQ Calming Soft Chew Calming Supplement for Dogs, 60 count
VetIQ Calming Soft Chew Calming Supplement for Dogs, 60 count
VetIQ Calming Soft Chew Calming Supplement for Dogs, 60 count
VetIQ Calming Soft Chew Calming Supplement for Dogs, 60 count

VetIQ Calming Soft Chew Calming Supplement for Dogs, 60 count

Rated 4.3 out of 5 stars
857
$9.97Chewy Price
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.3/5
Great

Effectiveness

4.3/5
Great

Ingredients

4.3/5
Great

Safety

4.3/5
Great

Is this dog calming care & anxiety supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients (per 3.5g soft chew) Chamomile (Matricaria recutita) 60mg, Vitamin B1 (Thiamine Mononitrate) 60mg, L-Tryptophan 30mg, L-Theanine 20mg, Passionflower (Passiflora incarnata) 20mg

Food Flavor

Hickory
5
Vibeful Calming Melatonin Peanut Butter Flavored Soft Chews Calming Supplement for Dogs, 90-Count
Vibeful Calming Melatonin Peanut Butter Flavored Soft Chews Calming Supplement for Dogs, 90-Count
Vibeful Calming Melatonin Peanut Butter Flavored Soft Chews Calming Supplement for Dogs, 90-Count
Vibeful Calming Melatonin Peanut Butter Flavored Soft Chews Calming Supplement for Dogs, 90-Count
Vibeful Calming Melatonin Peanut Butter Flavored Soft Chews Calming Supplement for Dogs, 90-Count
Vibeful Calming Melatonin Peanut Butter Flavored Soft Chews Calming Supplement for Dogs, 90-Count
Vibeful Calming Melatonin Peanut Butter Flavored Soft Chews Calming Supplement for Dogs, 90-Count
Vibeful Calming Melatonin Peanut Butter Flavored Soft Chews Calming Supplement for Dogs, 90-Count

Vibeful Calming Melatonin Peanut Butter Flavored Soft Chews Calming Supplement for Dogs, 90-Count

Rated 4.1 out of 5 stars
436
$19.99Chewy Price
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.3/5
Great

Effectiveness

4.3/5
Great

Ingredients

4.3/5
Great

Safety

4.3/5
Great

Is this dog calming care & anxiety supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Passionflower, Chamomile, Valerian Root, L-Tryptophan, Melatonin

Special Diet

Chicken-Free
6
ThunderShirt Classic Anxiety & Calming Vest for Dogs, Heather Grey, Large
ThunderShirt Classic Anxiety & Calming Vest for Dogs, Heather Grey, Large
ThunderShirt Classic Anxiety & Calming Vest for Dogs, Heather Grey, Large
ThunderShirt Classic Anxiety & Calming Vest for Dogs, Heather Grey, Large
ThunderShirt Classic Anxiety & Calming Vest for Dogs, Heather Grey, Large
ThunderShirt Classic Anxiety & Calming Vest for Dogs, Heather Grey, Large
ThunderShirt Classic Anxiety & Calming Vest for Dogs, Heather Grey, Large
ThunderShirt Classic Anxiety & Calming Vest for Dogs, Heather Grey, Large

ThunderShirt Classic Anxiety & Calming Vest for Dogs, Heather Grey, Large

Rated 4.1 out of 5 stars
2,177
$48.84Chewy Price
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

3.9/5
Good

Effectiveness

4.2/5
Great

Ingredients

4.2/5
Great

Safety

4.3/5
Great

Is this dog calming care & anxiety supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Closure Type

Velcro

Health Feature

Calming
7
Natural Farm Whole Pig Ears Dog Treats, 8 count
Natural Farm Whole Pig Ears Dog Treats, 8 count
Natural Farm Whole Pig Ears Dog Treats, 8 count

Natural Farm Whole Pig Ears Dog Treats, 8 count

Rated 4.6 out of 5 stars
403
$16.49Chewy Price
($2.07/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

3.9/5
Good

Effectiveness

4.1/5
Great

Ingredients

4.2/5
Great

Safety

4.2/5
Great

Is this dog calming care & anxiety supplement right for my pet?

Breed Size

All Breeds

Lifestage

Adult, All Lifestages

Top Ingredient

Pig Ear

Special Diet

Rawhide-Free, Grain-Free, High-Protein, Natural
8
VetriScience Composure Bacon Flavored Chews Calming Supplement for Dogs, 120 count
VetriScience Composure Bacon Flavored Chews Calming Supplement for Dogs, 120 count
VetriScience Composure Bacon Flavored Chews Calming Supplement for Dogs, 120 count
VetriScience Composure Bacon Flavored Chews Calming Supplement for Dogs, 120 count
VetriScience Composure Bacon Flavored Chews Calming Supplement for Dogs, 120 count
VetriScience Composure Bacon Flavored Chews Calming Supplement for Dogs, 120 count

VetriScience Composure Bacon Flavored Chews Calming Supplement for Dogs, 120 count

Rated 4.3 out of 5 stars
338
$33.00Chewy Price
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.4/5
Great

Effectiveness

4.3/5
Great

Ingredients

4.3/5
Great

Safety

4.4/5
Great

Is this dog calming care & anxiety supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Thiamine (Vitamin B1), Colostrum Calming Complex Biopeptide Blend, L-Theanine., Inactive Ingredients: Brewers Yeast, Calcium Sulfate

Food Flavor

Bacon, Meat
9
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle
Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle

Rescue Remedy Stress Relief Pet Supplement, 20-mL bottle

Rated 4.1 out of 5 stars
1,461
$20.99Chewy Price
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.2/5
Great

Effectiveness

4.3/5
Great

Ingredients

4.2/5
Great

Safety

4.3/5
Great

Is this dog calming care & anxiety supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

HPUS 5x Dilution of Helianthemum Nummularium, Clematis Vitalba, Impatiens Glandulifera, Prunus Cerasifera, Ornithogalum Umbellatum

Special Diet

Natural
10
NaturVet Hemp Quiet Moments Soft Chews Calming Supplement for Dogs, 180 count
NaturVet Hemp Quiet Moments Soft Chews Calming Supplement for Dogs, 180 count
NaturVet Hemp Quiet Moments Soft Chews Calming Supplement for Dogs, 180 count
NaturVet Hemp Quiet Moments Soft Chews Calming Supplement for Dogs, 180 count
NaturVet Hemp Quiet Moments Soft Chews Calming Supplement for Dogs, 180 count
NaturVet Hemp Quiet Moments Soft Chews Calming Supplement for Dogs, 180 count
NaturVet Hemp Quiet Moments Soft Chews Calming Supplement for Dogs, 180 count
NaturVet Hemp Quiet Moments Soft Chews Calming Supplement for Dogs, 180 count

NaturVet Hemp Quiet Moments Soft Chews Calming Supplement for Dogs, 180 count

Rated 4.1 out of 5 stars
1,021
$29.99Chewy Price
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage

4.2/5
Great

Effectiveness

4.2/5
Great

Ingredients

4.1/5
Great

Safety

4.2/5
Great

Is this dog calming care & anxiety supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Hemp Seed Oil, Hemp Seed Powder, Chamomile, Ginger, Passion Flower

Food Flavor

Unflavored

Frequently Asked Questions about Dog Calming Care & Anxiety Supplements

How often can I give my dog calming supplements for anxiety?

You can usually give your dog calming supplements for anxiety as often as the package recommends. Different calming supplements have different ingredients and periods of efficacy, so it is important to follow dosage frequency and quantity recommendations. Some calming supplements may be designed to be given daily, while others are made to be given on an as-needed basis. When in doubt, always ask your vet for guidance.

How many calming and anxiety treats can a dog have a day?

A dog can usually have as many calming and anxiety treats a day as the product packaging recommends. Read and follow all supplement directions closely for maximum efficacy and safety. You can also ask your vet for advice on how often to give your dog calming and anxiety treats.